Significant bone loss after stopping long-term denosumab treatment: a post FREEDOM study.

María Belén ZanchettaJ BoailchukF MassariF SilveiraC BogadoJ R Zanchetta

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017)

Our results describe the rapid bone loss occurring after cessation of denosumab treatment. Further studies are needed to assess if patients have a higher risk of fracture after stopping DMAb and if so, which patients have the highest risk, and assess the role of transitioning to bisphosphonates in the long term.

Keyphrases

bone loss
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
bone mineral density
quantum dots