Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.
Keyphrases
- blood pressure
- inflammatory response
- neuropathic pain
- resting state
- cerebral ischemia
- white matter
- induced apoptosis
- hypertensive patients
- functional connectivity
- cell cycle arrest
- heart rate
- spinal cord
- spinal cord injury
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- brain injury
- multiple sclerosis
- blood brain barrier
- skeletal muscle
- arterial hypertension