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A Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer.

Kuei-Ting ChenRussell W MadisonJay MooreDexter JinZoe FleischmannJustin NewbergAlexa SchrockNeeru BhardwajKatherine T LofgrenJie HeGarrett FramptonPriti HegdeDavid FabrizioMichael J PishvaianEricka EbotAatur SinghiEthan Sokol
Published in: The oncologist (2023)
A scar-based HRD biomarker was identified in a significant fraction of PC patients and is predictive of FOLFIRINOX benefit. Incorporating a biomarker like HRDsig could identify the right patients for platinum chemotherapy and potentially reduce FOLFIRINOX use by over 40%, minimizing toxicities with similar survival outcomes. Confirmatory studies should be performed.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • locally advanced
  • small cell lung cancer
  • peritoneal dialysis
  • prognostic factors
  • patient reported