Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips.
Fuze JiangZhen XiaoTing WangJiajia WangLihua BieLanja SalehKathrin FreyLianjun ZhangJing WangPublished in: Chemical communications (Cambridge, England) (2022)
We report protein- and aptamer-based electrochemical biochips for low-cost, one-step, sensitive and accurate multiplex detection of SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and IgG antibody in unprocessed clinical samples, allowing citizens to achieve rapid diagnosis at home or in community settings.
Keyphrases
- label free
- sars cov
- loop mediated isothermal amplification
- sensitive detection
- low cost
- respiratory syndrome coronavirus
- real time pcr
- gold nanoparticles
- high throughput
- coronavirus disease
- healthcare
- quantum dots
- high resolution
- mental health
- dendritic cells
- binding protein
- protein protein
- mass spectrometry
- small molecule
- tandem mass spectrometry
- energy transfer
- magnetic nanoparticles