Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.

Anaís Sánchez-CastilloElien HeylenJudith HounjetKim G SavelkoulsNatasja G LieuwesRianne BiemansLudwig J DuboisKobe ReyndersKasper M RouschopRianne D W VaesKim De KeersmaeckerMaarten LambrechtLizza E L HendriksDirk K M De RuysscherMarc A Vooijs Kim Rosalie Kampen

Published in: British journal of cancer (2023)

Our findings highlight that targeting serine/glycine metabolism using sertraline restricts cancer cell recovery from radiotherapy and provides tumor control through immunomodulation in NSCLC.

Keyphrases

early stage
locally advanced
cancer therapy
radiation therapy
small cell lung cancer
radiation induced
protein kinase
squamous cell carcinoma
advanced non small cell lung cancer
rectal cancer
drug delivery
brain metastases