Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis.

Laura BesendorfTanja Martina MüllerCarol-Immanuel GeppertInes SchneiderLaura MühlImke AtreyaFrancesco VitaliGisela FeltenMarkus F NeurathSebastian Zundler

Published in: Therapeutic advances in gastroenterology (2022)

Our data suggest that α4β7 mediates gut homing of T cells also in MC and that, on single cell level, vedolizumab blocks the function of α4β7 in MC. Thus, we provide mechanistic evidence supporting vedolizumab as promising therapeutic option for MC.

Keyphrases

ulcerative colitis
cell adhesion
patients with inflammatory bowel disease
single cell
rna seq
electronic health record
big data
high throughput
machine learning
data analysis
deep learning