Characterisation of age and polarity at onset in bipolar disorder.
Janos L KalmanLoes M Olde LoohuisAnnabel VreekerAndrew McQuillinEli A StahlDouglas RuderferMaria Grigoroiu-SerbanescuGeorgia PanagiotaropoulouStephan RipkeTim B BigdeliFrederike SteinTina MellerSusanne MeinertHelena PelinFabian StreitSergi PapiolMark James AdamsRolf AdolfssonKristina AdorjanIngrid AgartzSofie R AminoffHeike Anderson-SchmidtOle A AndreassenRaffaella ArdauJean-Michel AubryCeylan BalabanNicholas BassBernhard T BauneFrank BellivierAntoni BenabarreSusanne BengesserWade H BerrettiniMarco P BoksEvelyn J BrometKatharina BroschMonika BuddeWilliam ByerleyPablo CervantesCatina ChillottiSven CichonScott R ClarkAshley L ComesAiden CorvinWilliam CoryellNick CraddockDavid W CraigPaul E CroarkinCristiana CruceanuPiotr M CzerskiNina DalknerUdo DannlowskiFranziska DegenhardtMaria Del ZompoJ Raymond DePauloSrdjan DjurovicHoward J EdenbergMariam Al EissaTorbjørn ElvsåshagenBruno EtainAyman H FanousFrederike FellendorfAlessia FiorentinoAndreas J ForstnerMark A FryeJanice M FullertonKathrin GadeJulie GarnhamElliot GershonMichael GillFernando S GoesKatherine Gordon-SmithPaul GrofJose Guzman-ParraTim HahnRoland HaslerMaria HeilbronnerUrs HeilbronnerStephane JamainEsther JimenezIan JonesLisa A JonesLina JonssonRene S KahnJohn R KelsoeJames L KennedyTilo KircherGeorge KirovSarah Kittel-SchneiderFarah Klöhn-SaghatolislamJames A KnowlesThorsten M KranzTrine Vik LagerbergMikael LandenWilliam B LawsonMarion LeboyerQingqin S LiMario MajDolores MalaspinaMirko ManchiaFermin MayoralSusan L McElroyMelvin G McInnisAndrew M McIntoshHelena MedeirosIngrid MelleVihra MilanovaPhilip B MitchellPalmiero MonteleoneAlessio Maria MonteleoneMarkus M NöthenTomas NovakMichael C NealeNiamh O'BrienKevin S O'ConnellClaire O'DonovanMichael C O'DonovanNils OpelAbigail OrtizMichael J OwenErik PålssonCarlos PatoMichele T PatoJoanna PawlakJulia-Katharina PfarrClaudia PisanuJames B PotashMark H RapaportDaniela Reich-ErkelenzAndreas ReifEva ReininghausJonathan ReppleHélène Richard-LepourielMarcella RietschelKai RingwaldGloria RobertsGuy RouleauSabrina SchauppWilliam A ScheftnerSimon SchmittPeter R SchofieldK Oliver SchubertEva C SchulteBarbara SchweizerFanny SennerGiovanni SeverinoSally SharpClaire SlaneyOlav B SmelandJanet L SobellAlessio SquassinaPavla StopkovaJohn StraussAlfonso TortorellaGustavo TureckiJoanna Twarowska-HauserMarin VeldicEduard VietaJohn B VincentWei XuClement C ZaiPeter P Zandinull nullnull nullnull nullArianna Di FlorioJordan W SmollerJoanna M BiernackaFrancis J McMahonMartin AldaBertram Müller-MyhsokNikolaos KoutsoulerisPeter FalkaiNelson B FreimerTill F M AndlauerThomas G SchulzeRoel A OphoffPublished in: The British journal of psychiatry : the journal of mental science (2022)
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.