Neurofilament light oligomers in neurodegenerative diseases: quantification by homogeneous immunoassay in cerebrospinal fluid.

Francisco J MedaKathryn KnowlesImogen Joanna Swift Aitana Sogorb-Esteve Jonathan Daniel RohrerAnna DittrichIngmar SkoogSilke KernBruno BeckerKaj BlennowUlf AndreassonHlin KvartsbergHenrik Zetterberg

Published in: BMJ neurology open (2023)

The homogeneous ELISA and SEC data suggest that most of the NfL in both the calibrator and human CSF is present as a dimer. In CSF, the dimer appears to be truncated. Further studies are needed to determine its precise molecular composition.

Keyphrases

cerebrospinal fluid
endothelial cells
electronic health record
induced pluripotent stem cells
big data
sensitive detection
case control
single molecule
monoclonal antibody
machine learning
data analysis
artificial intelligence
quantum dots