Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium.

Se Ho Kim Jae Yeon Kim Soo Young Park Won Tae Jeong Jin Man Kim Si Hyun Bae Gi Jin Kim

Published in: Stem cell research & therapy (2021)

These findings suggest that PD-MSCsPRL-1 improved hepatic functions via calcium changes and attenuated ER stress in a BDL-injured rat model. Therefore, these results provide useful data for the development of next-generation MSC-based stem cell therapy for regenerative medicine in chronic liver disease.

Keyphrases

stem cells
small cell lung cancer
epidermal growth factor receptor
electronic health record
tyrosine kinase
big data
mouse model
machine learning
data analysis
bone marrow
mesenchymal stem cells
artificial intelligence
cell therapy