Metal-Organic Frameworks as Drug Delivery Platforms for Ocular Therapeutics.
Jesus Gandara-LoeIsabel Ortuño-LizaránLaura Fernández-SanchezJorge L AlióNicolás CuencaAlfredo Vega-EstradaJoaquín Silvestre-AlberoPublished in: ACS applied materials & interfaces (2019)
Metal-organic frameworks (MOFs) have been evaluated as potential nanocarriers for intraocular incorporation of brimonidine tartrate to treat chronic glaucoma. Experimental results show that UiO-67 and MIL-100 (Fe) exhibit the highest loading capacity with values up to 50-60 wt %, whereas the performance is quite limited for MOFs with narrow cavities (below 0.8 nm, for example, UiO-66 and HKUST-1). The large loading capacity in UiO-67 is accompanied by an irreversible structural amorphization in aqueous and physiological media that promotes extended release kinetics above 12 days. Compared to the traditional drawbacks associated with the sudden release of the commercial drugs (e.g., ALPHAGAN), these results anticipate UiO-67 as a potential nanocarrier for drug delivery in intraocular therapeutics. These promising results are further supported by cytotoxicity tests using retinal photoreceptor cells (661W). Toxicity of these structures (including the metal nodes and organic ligands) for retinal cells is rather low for all samples evaluated, except for HKUST-1.
Keyphrases
- metal organic framework
- drug delivery
- induced apoptosis
- cancer therapy
- cell cycle arrest
- optic nerve
- optical coherence tomography
- drug release
- small molecule
- diabetic retinopathy
- oxidative stress
- cataract surgery
- photodynamic therapy
- high resolution
- endoplasmic reticulum stress
- mass spectrometry
- ionic liquid
- neoadjuvant chemotherapy
- water soluble
- climate change
- risk assessment