Mitigating effects of antioxidant properties of Artemisia herba alba aqueous extract on hyperlipidemia and oxidative damage in alloxan-induced diabetic rats.
Omar SekiouMahieddine BoumendjelFaiza TaibiAmel BoumendjelMahfoud MessarahPublished in: Archives of physiology and biochemistry (2018)
Chronic hyperglycemia and excess reactive oxygen species overproduced in diabetes were associated with oxidative stress, led to continuous injury and functions damage to different organs: eyes, kidneys, neural and cardiovascular system. The present study was undertaken to evaluate the protective effect of Artemisia herba alba (AHA) leaf powder against alloxane-induced oxidative damage in diabetic rats. Rats were randomly divided into four groups: Group I controls received saline solution 9%; Group II was treated with 150 mg alloxane/(kg body weight) administered by intraperitoneal. Rats of Group III have received saline solution and treated with 400 mg AHA/(kg body weight). Animals of Group IV were treated with alloxane and AHA. Alloxane exposure led to increased blood glucose, total cholesterol, triglycerides, malondialdehyde, and a decrease in the antioxidants enzymes activities (catalase, glutathione peroxidase and glutathione-S-transferase). Administration of AHA aqueous extract ameliorated these parameters. These results demonstrate that AHA ameliorates hyperglycemia, hyperlipidemia and oxidative damage in alloxan-induced diabetes in rats.
Keyphrases
- diabetic rats
- oxidative stress
- body weight
- dna damage
- ischemia reperfusion injury
- blood glucose
- induced apoptosis
- glycemic control
- type diabetes
- reactive oxygen species
- cardiovascular disease
- high fat diet
- blood pressure
- ionic liquid
- nitric oxide
- hydrogen peroxide
- adipose tissue
- insulin resistance
- anti inflammatory
- stress induced
- endothelial cells