Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
James YarmolinskyJamie W RobinsonDaniela MariosaVille KarhunenJian HuangNiki DimouNeil MurphyKimberley BurrowsEmmanouil BourasKarl Smith-ByrneSarah J LewisTessel E GaleslootLambertus A KiemeneySita VermeulenPaul MartinDemetrius AlbanesLifang HouPolly A NewcombEmily WhiteAlicja WolkAnna H WuLoïc Le MarchandAmanda I PhippsDaniel D Buchanannull nullnull nullSizheng Steven ZhaoDipender GillStephen J ChanockMark P PurdueGeorge Davey SmithPaul BrennanKarl-Heinz HerzigMarjo-Riitta JarvelinAbbas DehghanMattias JohanssonMarc J GunterKostas K TsilidisRichard M MartinPublished in: medRxiv : the preprint server for health sciences (2023)
Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 5 circulating inflammatory markers in risk of 5 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated.