Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules.
Yuuya KawasakiTomoya HayashibaraYuki SetoYutaro TaniguchiKazunobu IgawaKatsuhiko TomookaPublished in: Chemical communications (Cambridge, England) (2023)
DACN-NHS-ester and DACN-maleimide were developed as molecular connectors and applied for the synthesis of artificial hybrid biomolecules in two steps, including, step 1: connection to a corresponding molecule via the NHS ester or maleimide unit, followed by step 2: connection to a corresponding azido-containing molecule via DACN unit by copper-free-alkyne-azide-cycloaddition.
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