Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice.
Ahmad J H AlbaghdadiMelanie A HewittSamantha M PutosMichael WellsTerence R S OzolinšFrederick W K KanPublished in: Journal of translational medicine (2017)
Our present data suggest a casual association between chronic maternal overnutrition and aberrancy in the maternal Th1-immune maladaptation to pregnancy and defective spiral artery modification, placental insufficiency and adverse fetal outcomes in the T2DM subjects. Further safety studies into the use of tacrolimus in the pre-pregnancy glycemic control may be beneficial.
Keyphrases
- pregnancy outcomes
- glycemic control
- type diabetes
- weight loss
- pregnant women
- blood glucose
- insulin resistance
- adipose tissue
- metabolic syndrome
- bariatric surgery
- electronic health record
- cardiovascular disease
- adverse drug
- emergency department
- case control
- skeletal muscle
- body mass index
- weight gain
- physical activity
- obese patients
- birth weight
- gestational age
- data analysis