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Melanocytic Panfolliculoma: A Case Report of a Rare Benign Follicular Tumor.

Allie PrestonCameron WestMartha McColloughGregory A Hosler
Published in: The American Journal of dermatopathology (2022)
Panfolliculomas (PF) are rare, benign, follicular tumors that differentiate toward multiple components of the hair follicle, and several variants have been described. We present a case of a rare pigmented PF presenting on actinically damaged skin in an 83-year-old man, which was clinically concerning for malignancy. This tumor arose near an area of atypical squamous proliferation and has evidence of infundibular, outer root sheath, and matrical differentiation and foci of heavy melanin pigmentation and increased melanocytes. We propose the novel designation of "melanocytic PF," akin to melanocytic matricoma but with panfollicular differentiation.
Keyphrases
  • signaling pathway
  • high grade
  • copy number
  • soft tissue
  • gene expression
  • dna methylation
  • wound healing