Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma.

Ju Youn LeeMichail SchizasFelipe C GeyerPier SelenicaSalvatore PiscuoglioRita A SakrCharlotte C K NgJose V Scarpa CarnielloRussell TowersDilip D GiriVictor Piana AndradeAnastasios D PapanastasiouAgnes VialeReuben S HarrisDavid B SolitBritta WeigeltJorge S Reis-FilhoTari A King

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our findings support the contention that LCIS has a repertoire of somatic genetic alterations similar to that of ILCs, and likely constitutes a nonobligate precursor of breast cancer. Intralesion genetic heterogeneity is observed in LCIS and should be considered in studies aiming to develop biomarkers of progression from LCIS to more advanced lesions.

Keyphrases

copy number
genome wide
single cell
high grade
gene expression
high throughput sequencing
breast cancer risk