The Protective Effect of Testosterone on the Ovarian Reserve During Cyclophosphamide Treatment.

Masae Yoo Tomohito Tanaka Hiromi KonishiAkiko TanabeKohei Taniguchi Kazumasa KomuraMasami HayashiMasahide Ohmichi

Published in: OncoTargets and therapy (2020)

These findings indicated that testosterone has the potential to prevent ovarian damage induced by cyclophosphamide by protecting granulosa cells from cyclophosphamide-induced apoptosis.

Keyphrases

induced apoptosis
high dose
low dose
oxidative stress
endoplasmic reticulum stress
replacement therapy
signaling pathway
risk assessment
adipose tissue
combination therapy
human health