Laser capture microscopy (LCM)-RNAseq for topological mapping of synovial pathology during rheumatoid arthritis.

Benjamin Van EspenE Barton PrideauxAndrew R WilsonCamilla R L MachadoSho SendoJames ParkerGrégory SeumoisCristiano SacchettiAnna C BelongiaNarayanan B PerumalPandurangan VijayanandMatthew D LinnikRobert J BenschopWei WangNunzio Bottini Gary S Firestein Stephanie M Stanford

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

LCM-RNAseq confirms reported transcriptional differences between RA and OA synovium and provides evidence supporting a relationship between synovial topology and molecular anomalies in RA.

Keyphrases

rheumatoid arthritis
disease activity
high resolution
single molecule
high speed
ankylosing spondylitis
interstitial lung disease
gene expression
systemic lupus erythematosus
transcription factor
knee osteoarthritis
high throughput
optical coherence tomography
high density
label free