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An exact approach for studying cargo transport by an ensemble of molecular motors.

Donatello MaterassiSubhrajit RoychowdhuryThomas HaysMurti Salapaka
Published in: BMC biophysics (2013)
Under this novel probabilistic approach new insights about the mechanisms of action of these proteins are found, suggesting hypothesis about their behavior and driving the design and realization of new experiments.The advantages provided in accuracy and efficiency make it possible to detect rare events in the motor protein dynamics, that could otherwise pass undetected using standard simulation methods. In this respect, the model has allowed to provide a possible explanation for possible mechanisms under which motor proteins could coordinate their motion.
Keyphrases
  • density functional theory
  • protein protein
  • binding protein
  • small molecule
  • neural network
  • molecular dynamics