DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.

Noboru TsudaYing TianMao FujimotoJunko KuramotoSatomi MakiuchiHidenori OjimaMasahiro GotohNobuyoshi HiraokaTeruhiko YoshidaYae Kanai Eri Arai

Published in: Journal of cancer research and clinical oncology (2022)

These data indicate that DNA methylation profiles may determine the clinicopathological heterogeneity of NASH-related HCCs via alterations of tumor-related gene expression.

Keyphrases

dna methylation
gene expression
genome wide
single cell
electronic health record
high grade
artificial intelligence
drug induced