DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.
Noboru TsudaYing TianMao FujimotoJunko KuramotoSatomi MakiuchiHidenori OjimaMasahiro GotohNobuyoshi HiraokaTeruhiko YoshidaYae KanaiEri AraiPublished in: Journal of cancer research and clinical oncology (2022)
These data indicate that DNA methylation profiles may determine the clinicopathological heterogeneity of NASH-related HCCs via alterations of tumor-related gene expression.