Common Factors Underlying Diverse Responses in Alcohol Use Disorder.
Esha CheboluMelanie L SchwandtVijay A RamchandaniBethany L StanglDavid T GeorgeYvonne HornefferTonette VinsonEmily L VogtBrandon A ManorNancy DiazgranadosDavid GoldmanPublished in: Psychiatric research and clinical practice (2021)
Diverse items from the ADS concurrently load onto three correlated alcohol response factors rather than loading independently. Genetic ancestry and clinical characteristics predicted the severity of items that define the alcohol response factors even after accounting for degree of alcohol consumption. Co-occurring phenotypes point towards an underlying shared physiology of diverse alcohol responses.