Household size, T regulatory cell development, and early allergic disease: a birth cohort study.
Anne-Louise PonsonbyFiona CollierMartin O'HelyMimi L K TangSarath RanganathanLawrence E K GrayEllen MorwitchRichard SafferyDavid BurgnerTerence DwyerPeter D SlyLeonard C HarrisonPeter J Vuillerminnull nullPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
Multiple prenatal and postnatal microbial factors are associated with nTreg and aTreg development. Larger household size was associated with higher nTreg at birth which in turn was associated with reduced allergic sensitization and disease at 12 months of age.