Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis.
Theresa Wampler MuskardinPriyanka VashishtJessica M DorschnerMark A JensenBeverly S ChrabotMarlena KernJeffrey R CurtisMaria I DanilaStacey S CofieldNancy ShadickPeter A NigrovicE William St ClairClifton O BinghamRichard FurieWilliam RobinsonMark GenoveseChristopher C StriebichJames R O'DellGeoffrey M ThieleLarry W MorelandMarc LevesqueS Louis BridgesPeter K GregersenTimothy B NiewoldPublished in: Annals of the rheumatic diseases (2015)
Increased pretreatment serum IFN-β/α ratio strongly associated with non-response to TNF inhibition. This study supports further investigation of serum type I IFN in predicting outcome of TNF inhibition in RA.