Inhibitor of nuclear factor kappa-B kinase epsilon contributes to neuropsychiatric manifestations in lupus-prone mice through microglial activation.
Kohei KarinoMichihito KonoShuhei TakeyamaYuki KudoMasatoshi KandaNobuya Abe DrKuniyuki AsoYuichiro FujiedaMasaru KatoKenji OkuOlga AmengualTatsuya AtsumiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
These findings suggest that IKBKE plays a vital role in the pathogenesis of NPSLE via microglial activation, and it could serve as a therapeutic target for NPSLE.
Keyphrases
- nuclear factor
- toll like receptor
- inflammatory response
- lipopolysaccharide induced
- neuropathic pain
- lps induced
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis
- tyrosine kinase
- metabolic syndrome
- immune response
- high fat diet induced
- type diabetes
- protein kinase
- skeletal muscle
- spinal cord injury
- adipose tissue
- wild type