When should factorial designs be used for late-phase randomised controlled trials?
Ian R WhiteAlexander J SzubertBabak Choodari-OskooeiA Sarah WalkerMahesh Kb ParmarPublished in: Clinical trials (London, England) (2023)
Factorial designs are not widely used and should be considered more often using our issues to consider. Low potential for at most small to modest interaction is key, for example, where the interventions have different mechanisms of action or target different aspects of the disease being studied.