3D printed bioresorbable scaffolds for articular cartilage tissue engineering: a comparative study between neat polycaprolactone (PCL) and poly(lactide-b-ethylene glycol) (PLA-PEG) block copolymer.
Uzuri UrtazaOlatz GuarestiIzar GorroñogoitiaAna Zubiarrain-LasernaEmma Muiños-LópezFroilán Granero-MoltóJ M Lamo de EspinosaTania López-MartinezManuel M MazoFelipe ProsperAne Miren ZalduaJon AnakabePublished in: Biomedical materials (Bristol, England) (2022)
This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable polycaprolactone and poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers were 3D printed with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested. Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.