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3D printed bioresorbable scaffolds for articular cartilage tissue engineering: a comparative study between neat polycaprolactone (PCL) and poly(lactide-b-ethylene glycol) (PLA-PEG) block copolymer.

Uzuri UrtazaOlatz GuarestiIzar GorroñogoitiaAna Zubiarrain-LasernaEmma Muiños-LópezFroilán Granero-MoltóJ M Lamo de EspinosaTania López-MartinezManuel M MazoFelipe ProsperAne Miren ZalduaJon Anakabe
Published in: Biomedical materials (Bristol, England) (2022)
This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable polycaprolactone and poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers were 3D printed with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested. Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.
Keyphrases
  • tissue engineering
  • induced apoptosis
  • healthcare
  • mesenchymal stem cells
  • cell cycle arrest
  • genome wide
  • drug release
  • signaling pathway
  • bone marrow
  • cell proliferation