The DURATIONS randomised trial design: Estimation targets, analysis methods and operating characteristics.

Matteo QuartagnoJames R CarpenterA Sarah WalkerMichelle ClementsMahesh Kb Parmar

Published in: Clinical trials (London, England) (2020)

Using the bootstrap to estimate the optimal duration in a DURATIONS design has good operating characteristics in a wide range of scenarios and can be used with confidence by researchers wishing to design a DURATIONS trial to reduce treatment duration. Uncertainty around several different targets can be estimated with this bootstrap approach.

Keyphrases

study protocol
clinical trial
climate change
open label
phase iii
phase ii
replacement therapy
double blind