Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults.
Jessica M DudaAmelia D MoserChun S ZuoFei DuXi ChenSarah PerloChristine E RichardsNara NascimentoMaria IronsideDavid J CrowleyLaura M HolsenMadhusmita MisraJames I HudsonJill M GoldsteinDiego A PizzagalliPublished in: Magnetic resonance in medicine (2020)
The present study found excellent GABA+ MRS repeatability and reliability in the dlPFC. The rACC showed inferior results, possibly because of a combination of shimming impedance and measurement error. These data suggest that MEGA-PRESS can be utilized to reliably distinguish participants based on dlPFC GABA+ levels, whereas the mixed results in the rACC merit further investigation.