Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia.

Nuole ZhuMiguel Santos-SantosIgnacio Illán-GalaVictor MontalTeresa EstellésIsabel BarroetaMiren AltunaJavier ArranzLaia MuñozOlivia BelbinIsabel SalaMaria Belén Sánchez-SaudinósAndrea SubiranaLaura VidelaJordi PeguerolesRafael BlesaJordi ClarimónMaria Carmona-IraguiJuan ForteaAlberto LleóDaniel Alcolea

Published in: Translational neurodegeneration (2021)

pGFAP and pNfL levels differ in FTD and AD, and their combination is useful for distinguishing between the two diseases. pGFAP could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

Keyphrases

cognitive decline
mild cognitive impairment
cerebrospinal fluid
protein protein
neuropathic pain
amino acid
binding protein
spinal cord injury
small molecule
spinal cord