MRI in the Evaluation of Locally Advanced Vulvar Cancer Treated with Chemoradiotherapy and Vulvar Cancer Recurrence: The 2021 Revision of FIGO Classification and the Need for Multidisciplinary Management.
Maura MiccòLuca RussoSalvatore PersianiMiriam DolciamiLucia ManganaroTeresa Margarida CunhaCatarina JanicasStefania Maria Rita RizzoOlivera NicolicGiorgia GarganeseLuca TagliaferriValentina LancellottaGiovanni ScambiaRiccardo ManfrediBenedetta GuiPublished in: Cancers (2022)
Magnetic resonance imaging (MRI) plays an essential role in the management of patients with locally advanced vulvar cancer (LAVC), who frequently benefit from a multidisciplinary approach. Accordingly, chemoradiotherapy (CRT) with radical or neoadjuvant intent seems to provide a better quality of life and less morbidity than extensive surgery alone. In this overview, we discuss the role of MRI in the post-CRT assessment of LAVC, emphasizing the evaluation of primary tumor response. In order to assess treatment response and select candidates for post-CRT local excision, the MRI findings are described according to signal intensity, restricted diffusion, enhancement, and invasion of adjacent organs. We also focus on the role of MRI in detecting vulvar cancer recurrence. It occurs in 30-50% of patients within two years after initial treatment, the majority appearing near the original resection margins or in ipsilateral inguinal or pelvic lymph nodes. Finally, we describe early and delayed complications of CRT, such as cellulitis, urethritis, vulvar edema, bone changes, myositis, and fistulization. By describing the role of MRI in assessing LAVC response to CRT and detecting recurrence, we hope to provide suitable indications for a personalized approach.
Keyphrases
- magnetic resonance imaging
- locally advanced
- contrast enhanced
- rectal cancer
- papillary thyroid
- diffusion weighted imaging
- lymph node
- sentinel lymph node
- squamous cell carcinoma
- neoadjuvant chemotherapy
- squamous cell
- cardiac resynchronization therapy
- computed tomography
- end stage renal disease
- minimally invasive
- heart failure
- prostate cancer
- magnetic resonance
- total knee arthroplasty
- left ventricular
- early stage
- free survival
- risk factors
- atrial fibrillation
- coronary artery disease
- peritoneal dialysis
- acute coronary syndrome
- soft tissue
- postmenopausal women