Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling.

Yiyun GengJingyuan XuWeichao LiQing LiChenjinxin ShenZhangshuang DengYiqing Zhou

Published in: Chemical communications (Cambridge, England) (2022)

We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action.

Keyphrases

single cell
quantum dots
living cells
human health
risk assessment
climate change
single molecule