Reactive oxygen and nitrogen species are crucial for the antifungal activity of amorolfine and ciclopirox olamine against the dermatophyte Trichophyton interdigitale.
Paulo H F CarmoGustavo J C FreitasJoão C M DornelasBruna C T AlmeidaLudmila M BaltazarGabriella F FerreiraNalu T A PeresDaniel de Assis SantosPublished in: Medical mycology (2022)
Onychomycosis is a nail infection, which can be treated with amorolfine and ciclopirox olamine. Here we demonstrate that these drugs exhibit antifungal activity also through the production of oxidative and nitrosative radicals.
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