Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury.

Markus Berger Oliveira João Alfredo de MoraesWalter Orlando Beys-da-SilvaLucélia SantiPaula Barros TerracianoDavid DriemeierElizabeth Obino Cirne-LimaEduardo Pandolfi PassosMaria Aparecida Ribeiro VieiraThereza Christina Barja-FidalgoJorge Almeida Guimarães

Published in: PLoS neglected tropical diseases (2019)

These data indicated that kallikrein and consequently kinin release have a key role in kidney injury and vascular remodeling. Thus, blocking kallikrein may be a therapeutic alternative to control the progression of venom-induced AKI and vascular disturbances.

Keyphrases

acute kidney injury
high glucose
diabetic rats
cardiac surgery
drug induced
endothelial cells
oxidative stress
electronic health record
big data
artificial intelligence
stress induced