Proton therapy reduces the effective dose to immune cells in breast cancer patients.

Pierre LoapJeremi Vu-BezinLudovic De MarziYoulia Kirova

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2024)

IMPT significantly reduced EDIC in BC patients undergoing locoregional adjuvant radiotherapy. Integral total dose reduction, associated with improved lung sparing in left-sided BC patients or liver sparing in right-sided BC patients, mainly drove EDIC reduction with IMPT. The emergence of dynamic models taking into account the circulatory kinetics of immune cells may improve the accuracy of the estimate of the dose received by the immune system compared to calculation of the EDIC, which is based solely on static dosimetric data.

Keyphrases

end stage renal disease
ejection fraction
patients undergoing
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
squamous cell carcinoma
electronic health record
deep learning
minimally invasive
big data
patient reported