In summary, Ag-np can modulate gene expression and protein functions in IMR-90 cells and U251 cells, leading to defective DNA repair, proliferation arrest and inflammatory response. The observed changes could also be due to its capability to adsorb cytosolic proteins on its surface.
Keyphrases
- dna repair
- cell cycle
- dna damage
- induced apoptosis
- gene expression
- inflammatory response
- silver nanoparticles
- cell cycle arrest
- dna damage response
- cell proliferation
- oxidative stress
- signaling pathway
- dna methylation
- endoplasmic reticulum stress
- cell death
- immune response
- reactive oxygen species
- highly efficient
- visible light