Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts.

Jonghae LeeSewon LeeHanrui ZhangMichael A HillCuihua ZhangYoonjung Park

Published in: PloS one (2017)

The interactions between TNF-α and IL-6 exacerbate oxidative stress and reduce phosphorylation of eNOS, thereby contributing to coronary endothelial dysfunction in T2D mice.

Keyphrases

oxidative stress
rheumatoid arthritis
coronary artery disease
coronary artery
endothelial cells
dna damage
high fat diet induced
pi k akt
heart failure
type diabetes
adipose tissue
induced apoptosis
protein kinase
nitric oxide
signaling pathway
left ventricular
transcatheter aortic valve replacement