Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia.

Umut AyparStephanie A SmoleyBeth A PitelKathryn E PearceRoman M ZenkaGeorge VasmatzisSarah H JohnsonJames B SmadbeckJess F PetersonKatherine B GeiersbachDaniel L Van DykeErik C ThorlandRobert B JenkinsRhett P KetterlingPatricia T GreippHutton M KearneyNicole L HoppmanLinda B Baughn

Published in: European journal of haematology (2018)

Utilization of MPseq represents a precise, molecular-based technique that can be used as an alternative to conventional cytogenetic studies for newly diagnosed AML patients with the potential to revolutionize the diagnosis of hematologic malignancies.

Keyphrases

newly diagnosed
acute myeloid leukemia
single cell
loop mediated isothermal amplification
copy number
real time pcr
label free
case control
allogeneic hematopoietic stem cell transplantation
human health
single molecule
quantum dots