Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences.
Danny BergeronLaurence Faucher-GiguèreAnn-Kathrin EmmerichsKarine ChoquetKristina Sungeun SongGabrielle Deschamps-FrancoeurÉtienne Fafard-CoutureAndrea RiveraSonia CoutureL Stirling ChurchmanFlorian HeydSherif Abou ElelaMichelle S ScottPublished in: Genome biology (2023)
Many snoRNAs form RNA duplexes near alternative exons of their host transcripts, placing them in optimal positions to control host output as shown for the SNORD2-EIF4A2 model system. Overall, our study supports a more widespread role for intronic snoRNAs in the regulation of their host transcript maturation.