cGAMP: A tale of two signals.
Teneema KuriakoseThirumala-Devi KannegantiPublished in: The Journal of experimental medicine (2017)
In this issue of JEM, Swanson et al. (https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.