Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS-evaluation of whole blood, plasma, and serum as sample matrices.
Henrik CarlssonKarin HjortonSandy AbujraisLars RönnblomTorbjörn ÅkerfeldtKim KultimaPublished in: Arthritis research & therapy (2020)
A LC-HRMS method for the measurement of HCQ in human blood was developed and validated. Whole blood was found to be the superior sample matrix in terms of sample reproducibility. Thus, whole blood samples should be used for HCQ analysis when patients are monitored for HCQ treatment effects. The assay is in clinical use to monitor levels of HCQ in patients.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- endothelial cells
- systemic lupus erythematosus
- rheumatoid arthritis
- mass spectrometry
- high throughput
- high resolution
- combination therapy
- simultaneous determination
- induced pluripotent stem cells