LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse.
Shimona StarlingClare JollyPublished in: Journal of virology (2016)
HIV-1 causes AIDS by spreading within immune cells and depletion of CD4 T lymphocytes. Rapid spread between these cells occurs by highly efficient cell-cell transmission that takes place at virological synapses (VS). VS are characterized by striking T cell remodeling that is spatially associated with polarized virus assembly and budding at sites of cell contact. Here, we show that the integrin LFA-1 triggers organelle polarization and viral protein recruitment, facilitating formation of the VS, and that this requires the T cell kinase ZAP70. Taken together, these data suggest a mechanism by which HIV-1-infected T cells sense and respond to cell contact to polarize viral egress and promote cell-cell spread. Understanding how cell-cell spread is regulated may help reveal therapeutic targets to specifically block this mode of HIV-1 dissemination.
Keyphrases
- hiv infected
- single cell
- antiretroviral therapy
- cell therapy
- hepatitis c virus
- sars cov
- highly efficient
- hiv positive
- hiv testing
- dna methylation
- men who have sex with men
- gene expression
- small molecule
- deep learning
- induced apoptosis
- social media
- transcription factor
- artificial intelligence
- big data
- pi k akt
- cell cycle arrest