Intra-Vial Heterogeneity in Physical Form of Mannitol in Colyophilized Binary Systems.
S ThakralS KoranneRaj SuryanarayananPublished in: Pharmaceutical research (2018)
The intra-vial heterogeneity and total MHH content in the final lyophile is a complex interplay of formulation composition and processing conditions. Graphical Abstract Figure depicting spatial heterogeneity in mannitol hemihydrate content, when mannitol is lyophilized with a cosolute, such as sucrose, trealose or lysozyme.