GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma.

Sonia CournoyerAnissa AddiouiAssila BelounisMona BeaunoyerCarine NyalendoRoxane Le GallPierre TeiraElie HaddadGilles VassalHervé Sartelet

Published in: BMC cancer (2019)

Based on the synergistic effect of HCQ and GX 15-070 observed in this study, the combination of these two drugs may be utilized as a new therapeutic approach for neuroblastoma.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell death
cell cycle arrest
signaling pathway
cancer therapy
anti inflammatory
drug induced
pi k akt