Role of Lysine-Specific Demethylase 1 in Metabolically Integrating Osteoclast Differentiation and Inflammatory Bone Resorption Through Hypoxia-Inducible Factor 1α and E2F1.

Kohei DoiKoichi MurataShuji ItoAkari SuzukiChikashi TeraoShinichiro IshieAkio UmemotoYoshiki MurotaniKohei NishitaniHiroyuki YoshitomiTakayuki FujiiRyu WatanabeMotomu HashimotoKosaku MurakamiMasao TanakaHiromu ItoKyung-Hyun Park-MinLionel B IvashkivAkio MorinobuShuichi Matsuda

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

LSD1 metabolically regulates osteoclastogenesis in an energy-demanding inflammatory environment. These findings provide potential new therapeutic strategies targeting osteoclasts in the management of inflammatory arthritis, including in patients with RA.

Keyphrases

bone loss
oxidative stress
rheumatoid arthritis
bone mineral density
cancer therapy
climate change
human health
soft tissue