Recombinant thrombomodulin lectin-like domain attenuates Porphyromonas gingivalis lipopolysaccharide-induced osteoclastogenesis and periodontal bone resorption.

Lan-Yun ChangChao-Han LaiCheng-Hsiang KuoBi-Ing ChangHua-Lin WuTsung-Lin Cheng

Published in: Journal of periodontology (2021)

Our study demonstrated that rTMD1 attenuates Pg-LPS-enhanced M1 macrophage polarization, osteoclastogenesis and periodontal bone resorption and thus holds therapeutic promise for periodontitis.

Keyphrases

bone loss
lipopolysaccharide induced
inflammatory response
lps induced
bone mineral density
soft tissue
big data
bone regeneration
anti inflammatory
body composition
postmenopausal women
artificial intelligence
cell free