Differences in bone microarchitecture between genetic and secondary iron-overload mouse models suggest a role for hepcidin deficiency in iron-related osteoporosis.
François RobinDaniel ChappardPatricia LeroyerChloé LatourGuillaume MabilleauValérie MonbetThibault CaveyMathieu HoreauFrédéric DerbréMarie-Paule RothMartine RopertPascal GuggenbuhlOlivier LoréalPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2023)
Together, these data suggest that iron in excess alone is not sufficient to induce osteoporosis and that low hepcidin levels also contribute to the development of osteoporosis.