Mouse models of Japanese encephalitis virus infection: A systematic review and meta-analysis using a meta-regression approach.
Tehmina BharuchaBen ClearyAlice FarmiloeElizabeth SuttonHanifah HayatiPeggy KirkwoodLayal Al HamedNadja van GinnekenKrishanthi S SubramaniamNicole ZitzmannGeriant DaviesLance TurtlePublished in: PLoS neglected tropical diseases (2022)
This is the first systematic review of mouse models of JEV infection. Better adherence to CAMARADES guidelines may reduce bias and variability of reporting. In particular, sample size calculations were notably absent. We report that mouse age, mouse strain, virus strain, virus dose and route of inoculation account for much, though not all, of the variation in mortality. This dataset is available for researchers to access and use as a guideline for JEV mouse experiments.