Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.
Hou-Wen LinJing LiMeng-Meng ZhangJie CuiYu-Han GuiYun ZhangJing-Ya LiKe-Chun LiuHou-Wen LinPublished in: Organic letters (2019)
The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 μM.
Keyphrases
- high resolution
- solid state
- electron microscopy
- electronic health record
- magnetic resonance
- protein protein
- mass spectrometry
- cancer therapy
- big data
- dual energy
- high resolution mass spectrometry
- binding protein
- computed tomography
- protein kinase
- small molecule
- machine learning
- artificial intelligence
- data analysis
- deep learning