Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis.
Albert ParesMitchell ShiffmanVictor VargasInvernizzi PietroElizabeth S MalechaAlexander LibermanLeigh MacConellGideon HirschfieldPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Obeticholic acid treatment was associated with significant reductions in total and direct bilirubin, particularly in patients with high baseline direct bilirubin. Because raised direct bilirubin levels, even within the normal range, are predictive of survival in primary biliary cholangitis, these results suggest substantial benefits of obeticholic acid in at-risk patients.
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