Inhibition of NR5A1 Phosphorylation Alleviates a Transcriptional Suppression Defect Caused by a Novel NR0B1 Mutation.

Ichiro Abe Tomoko Tanaka Kenji OheHideyuki FujiiMai NagataKentaro OchiYuki SendaKaori TakeshitaMidori KogaTadachika KudoMunechika EnjojiToshihiko YanaseKunihisa Kobayashi

Published in: Journal of the Endocrine Society (2022)

The specific reduction of NR5A1 phosphorylation by a CLK1/4 inhibitor may alleviate developmental defects in patients with NR0B1 mutations.

Keyphrases

transcription factor
mouse model
oxidative stress
heat shock protein